/* ───────── Psikofarmakoloji Rehberi — stil ───────── */
:root {
  color-scheme: light;
  --zemin: #f6f6f3;
  --yuzey: #fcfcfb;
  --yuzey-2: #f1f0ec;
  --murekkep: #0b0b0b;
  --murekkep-2: #52514e;
  --soluk: #898781;
  --cizgi: #e1e0d9;
  --eksen: #c3c2b7;
  --kenar: rgba(11,11,11,.10);
  --golge: 0 1px 2px rgba(11,11,11,.05), 0 6px 20px rgba(11,11,11,.05);

  --vurgu: #256abf;
  --vurgu-zemin: #e6f0fc;

  /* kategorik (ilaç sınıfı) */
  --s-ad: #2a78d6;
  --s-dehb: #eb6834;
  --s-ap: #6250d6;
  --s-dd: #1baf7a;
  --s-anks: #e87ba4;
  --s-diger: #0f9488;

  /* ardışık (tek ton) */
  --ton-1: #cde2fb;
  --ton-2: #86b6ef;
  --ton-3: #3987e5;
  --ton-4: #184f95;

  /* durum */
  --iyi: #0ca30c;
  --uyari: #fab219;
  --ciddi: #ec835a;
  --kritik: #d03b3b;
  --kritik-zemin: #fbeaea;
  --uyari-zemin: #fff5dc;
  --iyi-zemin: #e7f6e7;
}
@media (prefers-color-scheme: dark) {
  :root:where(:not([data-theme="light"])) {
    color-scheme: dark;
    --zemin: #0d0d0d; --yuzey: #1a1a19; --yuzey-2: #242422;
    --murekkep: #f0efec; --murekkep-2: #c3c2b7; --soluk: #898781;
    --cizgi: #2c2c2a; --eksen: #383835; --kenar: rgba(255,255,255,.10);
    --golge: 0 1px 2px rgba(0,0,0,.4);
    --vurgu: #6da7ec; --vurgu-zemin: #14283f;
    --s-ad: #3987e5; --s-dehb: #d95926; --s-ap: #9085e9; --s-dd: #199e70; --s-anks: #d55181; --s-diger: #14b8a6;
    --ton-1: #184f95; --ton-2: #256abf; --ton-3: #3987e5; --ton-4: #9ec5f4;
    --kritik-zemin: #3a1717; --uyari-zemin: #3a2d0c; --iyi-zemin: #12300f;
  }
}
:root[data-theme="dark"] {
  color-scheme: dark;
  --zemin: #0d0d0d; --yuzey: #1a1a19; --yuzey-2: #242422;
  --murekkep: #f0efec; --murekkep-2: #c3c2b7; --soluk: #898781;
  --cizgi: #2c2c2a; --eksen: #383835; --kenar: rgba(255,255,255,.10);
  --golge: 0 1px 2px rgba(0,0,0,.4);
  --vurgu: #6da7ec; --vurgu-zemin: #14283f;
  --s-ad: #3987e5; --s-dehb: #d95926; --s-ap: #9085e9; --s-dd: #199e70; --s-anks: #d55181; --s-diger: #14b8a6;
  --ton-1: #184f95; --ton-2: #256abf; --ton-3: #3987e5; --ton-4: #9ec5f4;
  --kritik-zemin: #3a1717; --uyari-zemin: #3a2d0c; --iyi-zemin: #12300f;
}

* { box-sizing: border-box; }
html { scroll-behavior: smooth; }
body {
  margin: 0; background: var(--zemin); color: var(--murekkep);
  font: 15px/1.55 system-ui, -apple-system, "Segoe UI", sans-serif;
  -webkit-font-smoothing: antialiased;
}
a { color: var(--vurgu); text-decoration: none; }
a:hover { text-decoration: underline; }
h1, h2, h3, h4 { margin: 0; line-height: 1.25; text-wrap: balance; }
p { margin: 0 0 .7em; }
ul { margin: 0; padding-left: 1.15em; }
li { margin: .25em 0; }
button { font: inherit; color: inherit; cursor: pointer; }
.kap { max-width: 1180px; margin: 0 auto; padding: 0 20px; }

/* ── üst bar ── */
.ust { position: sticky; top: 0; z-index: 20; background: color-mix(in srgb, var(--yuzey) 92%, transparent);
  backdrop-filter: blur(10px); border-bottom: 1px solid var(--cizgi); }
.ust-ic { max-width: 1180px; margin: 0 auto; padding: 10px 20px; display: flex; align-items: center; gap: 18px; flex-wrap: wrap; }
.marka { display: flex; align-items: center; gap: 10px; font-weight: 700; font-size: 18px; color: var(--murekkep); letter-spacing: -.01em; }
.marka:hover { text-decoration: none; }
.marka svg { color: var(--vurgu); }
.gezinti { display: flex; gap: 4px; margin-left: auto; flex-wrap: wrap; }
.gezinti a { padding: 7px 13px; border-radius: 8px; color: var(--murekkep-2); font-weight: 550; font-size: 14px; }
.gezinti a:hover { background: var(--yuzey-2); text-decoration: none; }
.gezinti a.aktif { background: var(--vurgu-zemin); color: var(--vurgu); }
.tema-dugme { border: 1px solid var(--cizgi); background: var(--yuzey); border-radius: 8px; width: 34px; height: 34px;
  display: grid; place-items: center; color: var(--murekkep-2); }
.tema-dugme:hover { background: var(--yuzey-2); }
.marka-bh { display: none; }

/* ── hasta grubu (çocuk-ergen / erişkin) ── */
:root:not([data-kitle="eri"]) [data-yalniz="eri"], :root[data-kitle="eri"] [data-yalniz="ped"] { display: none !important; }
/* marka adının altında küçük bir "baskı" seçicisi: üst bar tek satırda kalır */
.marka-blok { display: flex; flex-direction: column; align-items: flex-start; gap: 3px; min-width: 0; }
.kitle-sec { display: inline-flex; padding: 2px; gap: 2px; margin-left: var(--marka-girinti, 40px); background: var(--yuzey-2); border: 1px solid var(--cizgi); border-radius: 8px; flex: none; }
.kitle-sec button { border: 0; background: transparent; padding: 2px 9px; border-radius: 6px; font-size: 12px; font-weight: 600; color: var(--murekkep-2); white-space: nowrap; line-height: 1.35; }
.kitle-sec button:hover { color: var(--murekkep); }
.kitle-sec button[aria-checked="true"] { background: var(--yuzey); color: var(--vurgu); box-shadow: 0 1px 3px rgba(0,0,0,.14); }
.kitle-sec .kisa { display: none; }
@media (max-width: 520px) {
  .kitle-sec .uzun { display: none; } .kitle-sec .kisa { display: inline; }
  /* dar ekranda marka adı yerine seçici logonun yanında durur; ad ana sayfa başlığında zaten var */
  .marka-blok { flex-direction: row; align-items: center; gap: 10px; }
  .marka span { display: none; }
  .kitle-sec { margin-left: 0; }
  .kitle-sec button { font-size: 13px; padding: 4px 10px; }
}
/* telefon: marka + düğmeler tek satır, gezinti yatay kaydırmalı şerit (tüm tasarımlarda) */
@media (max-width: 760px) {
  .ust-ic { padding: 10px 16px 0; gap: 10px; flex-wrap: wrap; }
  .marka-blok { flex: 1; min-width: 0; }
  .marka { max-width: 100%; font-size: 16px; }
  .marka span { overflow: hidden; text-overflow: ellipsis; white-space: nowrap; }
  .tasarim-sec, #temaDugme { order: 2; }
  .gezinti { order: 3; flex: 1 0 100%; margin: 0 -16px; padding: 6px 12px 8px; flex-wrap: nowrap; overflow-x: auto; scrollbar-width: none; border-top: 1px solid var(--cizgi); }
  .gezinti::-webkit-scrollbar { display: none; }
  .gezinti a { white-space: nowrap; flex: none; }
}
.ped-ozet { margin: -8px 0 16px; }

/* ── Türkiye ruhsatı (KÜB) kutusu ── */
.tr-kub { margin: 0 0 16px; padding-top: 12px; border-top: 1px dashed var(--cizgi); }
.tr-kub > .alt-b { margin-top: 0; }
.tr-kaynak { display: inline-block; font-size: 10px; font-weight: 700; letter-spacing: .06em; padding: 1px 6px; margin-left: 6px; border-radius: 4px;
  background: var(--kritik); color: #fff; vertical-align: 1px; }
.etiket.tr { background: color-mix(in srgb, var(--kritik) 8%, var(--yuzey)); border-color: color-mix(in srgb, var(--kritik) 28%, var(--yuzey)); color: var(--murekkep); }
.etiket.tr::before { content: "✓"; }
.tr-kub .onaylar { margin-bottom: 6px; }
.tr-satir { margin: 2px 0 6px; max-width: 90ch; }
.tr-detay { margin-top: 4px; }
.tr-detay > summary { cursor: pointer; width: fit-content; padding: 3px 0; font-size: 13px; font-weight: 600; color: var(--vurgu); }
.tr-detay > summary:hover { text-decoration: underline; }
.tr-detay[open] > summary { margin-bottom: 4px; }
.tr-detay .alt-b { margin-top: 8px; }
.tr-detay .metin-kutular { margin-top: 10px; }
.tr-fark li { font-size: 14px; }

/* ── ilk açılış penceresi ── */
body.pencere-acik { overflow: hidden; }
.karsilama { position: fixed; inset: 0; z-index: 60; display: grid; place-items: center; padding: 16px; overflow-y: auto;
  background: rgba(10,10,10,.5); backdrop-filter: blur(3px); }
.karsilama-ic { width: min(760px, 100%); padding: 26px 28px 22px; margin: auto; }
.karsilama-bas h2 { font-size: 25px; letter-spacing: -.01em; margin-bottom: 4px; }
.karsilama-bas p { color: var(--murekkep-2); margin: 0 0 20px; max-width: 60ch; }
.karsilama-adim { display: flex; align-items: center; gap: 10px; font-weight: 700; font-size: 15.5px; margin: 4px 0 12px; }
.kitle-kartlar { display: grid; grid-template-columns: 1fr 1fr; gap: 12px; }
.kitle-kart, .tasarim-kart { text-align: left; border: 1.5px solid var(--cizgi); border-radius: 12px; background: var(--yuzey); color: var(--murekkep); transition: border-color .12s, box-shadow .12s; }
.kitle-kart { display: flex; gap: 13px; align-items: flex-start; padding: 15px; }
.kitle-kart b, .tasarim-kart b { display: block; font-size: 15.5px; }
.kitle-kart small, .tasarim-kart small { display: block; font-size: 12.5px; color: var(--murekkep-2); line-height: 1.4; margin-top: 3px; }
.kitle-simge { flex: none; width: 44px; height: 44px; border-radius: 11px; display: grid; place-items: center; background: var(--vurgu-zemin); color: var(--vurgu); }
.kitle-simge svg { width: 26px; height: 26px; }
.kitle-kart:hover, .tasarim-kart:hover { border-color: var(--eksen); }
.kitle-kart[aria-checked="true"], .tasarim-kart[aria-checked="true"] { border-color: var(--vurgu); box-shadow: 0 0 0 3px var(--vurgu-zemin); }
.karsilama-not { margin: 10px 0 20px; }
.tasarim-kartlar { display: grid; grid-template-columns: repeat(4, minmax(0, 1fr)); gap: 10px; }
.tasarim-kart { display: flex; flex-direction: column; align-items: flex-start; gap: 9px; padding: 12px; }
.tasarim-kart b { font-size: 14.5px; }
.tasarim-kart small { font-size: 12px; }
.karsilama-alt { display: flex; align-items: center; justify-content: space-between; gap: 12px; flex-wrap: wrap; margin-top: 22px;
  padding-top: 16px; border-top: 1px solid var(--cizgi); }
.karsilama-tamam { padding: 10px 22px; font-size: 15px; }
.karsilama-tamam:disabled { opacity: .4; cursor: not-allowed; }
@media (max-width: 680px) {
  .karsilama { place-items: start center; }
  .karsilama-ic { padding: 20px 18px 18px; }
  .kitle-kartlar { grid-template-columns: 1fr; }
  .tasarim-kartlar { grid-template-columns: 1fr 1fr; }
}

/* ── tasarım seçici ── */
.tasarim-sec { position: relative; }
.tasarim-menu { position: absolute; right: 0; top: calc(100% + 8px); z-index: 40; width: 270px; padding: 6px;
  background: var(--yuzey); border: 1px solid var(--cizgi); border-radius: 12px; box-shadow: 0 10px 30px rgba(0,0,0,.16); }
.tasarim-menu[hidden] { display: none; }
.tasarim-menu-baslik { font-size: 11.5px; font-weight: 700; text-transform: uppercase; letter-spacing: .06em; color: var(--soluk); padding: 6px 8px 4px; }
.tasarim-menu button { display: flex; align-items: center; gap: 11px; width: 100%; text-align: left; border: 0; background: transparent;
  padding: 8px; border-radius: 8px; }
.tasarim-menu button:hover, .tasarim-menu button:focus-visible { background: var(--yuzey-2); outline: none; }
.tasarim-menu button[aria-checked="true"] { background: var(--vurgu-zemin); }
.tasarim-menu b { display: block; font-size: 14px; }
.tasarim-menu small { display: block; font-size: 12px; color: var(--murekkep-2); line-height: 1.3; }
.ornek { flex: none; display: grid; grid-template-columns: repeat(3, 1fr); width: 46px; height: 30px; border-radius: 6px; overflow: hidden;
  border: 1px solid var(--cizgi); }
.ornek i { display: block; }
.ornek-klasik { background: #f6f6f3; padding: 7px 5px; gap: 3px; }
.ornek-klasik i { border-radius: 50%; aspect-ratio: 1; align-self: center; }
.ornek-klasik i:nth-child(1) { background: #2a78d6; } .ornek-klasik i:nth-child(2) { background: #6250d6; } .ornek-klasik i:nth-child(3) { background: #1baf7a; }
.ornek-bauhaus { border: 2px solid #111; border-radius: 0; }
.ornek-bauhaus i:nth-child(1) { background: #d92b1c; } .ornek-bauhaus i:nth-child(2) { background: #f4be1b; border-left: 2px solid #111; border-right: 2px solid #111; } .ornek-bauhaus i:nth-child(3) { background: #1e4fa0; }
.ornek-isvicre { background: #fff; grid-template-columns: 1fr 2fr; border-radius: 0; border-color: #111; }
.ornek-isvicre i:nth-child(1) { background: #e30613; } .ornek-isvicre i:nth-child(2) { background: linear-gradient(#111 0 2px, transparent 2px 9px, #111 9px 10px, transparent 10px 17px, #111 17px 18px, transparent 18px); margin: 5px 4px; } .ornek-isvicre i:nth-child(3) { display: none; }
.ornek-farmakope { background: #f4efe3; grid-template-columns: 1fr; place-items: center; border-color: #cfc5ae; }
.ornek-farmakope i:nth-child(1) { width: 26px; height: 2px; background: #7a2230; } .ornek-farmakope i:nth-child(2) { font: italic 700 13px/1 Georgia, serif; color: #1f2a44; }
.ornek-farmakope i:nth-child(2)::before { content: "Rx"; } .ornek-farmakope i:nth-child(3) { width: 26px; height: 2px; background: #7a2230; }

main.kap { padding-top: 26px; padding-bottom: 40px; min-height: 70vh; }
.alt { font-size: 12.5px; color: var(--murekkep-2); padding-top: 18px; padding-bottom: 36px; border-top: 1px solid var(--cizgi); }

/* ── ortak bileşenler ── */
.kart { background: var(--yuzey); border: 1px solid var(--kenar); border-radius: 14px; box-shadow: var(--golge); }
.bolum { padding: 22px 24px; margin-bottom: 18px; scroll-margin-top: 130px; }
.bolum > h2 { font-size: 18px; margin-bottom: 4px; display: flex; align-items: center; gap: 10px; }
.bolum > .alt-baslik { color: var(--murekkep-2); font-size: 13.5px; margin-bottom: 16px; }
.no { display: inline-grid; place-items: center; width: 26px; height: 26px; border-radius: 50%;
  background: var(--sinif, var(--vurgu)); color: #fff; font-size: 13px; font-weight: 700; flex: none; }
.etiket { display: inline-flex; align-items: center; gap: 6px; padding: 3px 10px; border-radius: 12px; font-size: 12px; font-weight: 600;
  background: var(--yuzey-2); color: var(--murekkep-2); border: 1px solid var(--cizgi); max-width: 100%; line-height: 1.35; }
.etiket .nokta { width: 8px; height: 8px; border-radius: 50%; background: var(--sinif, var(--soluk)); }
.etiket.onay { background: var(--iyi-zemin); border-color: transparent; color: var(--murekkep); }
.etiket.onaysiz { background: var(--uyari-zemin); border-color: transparent; color: var(--murekkep); }
.kucuk { font-size: 12.5px; color: var(--murekkep-2); }
.soluk { color: var(--soluk); }
.izgara-2 { display: grid; grid-template-columns: minmax(0, 1fr) minmax(0, 1.25fr); gap: 22px; align-items: start; }
@media (max-width: 860px) { .izgara-2 { grid-template-columns: 1fr; } }

.cagri { border-radius: 10px; padding: 11px 14px; font-size: 13.5px; display: flex; gap: 10px; align-items: flex-start; margin: 10px 0; }
.cagri svg { flex: none; margin-top: 2px; }
.cagri.kritik { background: var(--kritik-zemin); }
.cagri.kritik svg { color: var(--kritik); }
.cagri.uyari { background: var(--uyari-zemin); }
.cagri.uyari svg { color: #b97c00; }
.cagri.bilgi { background: var(--vurgu-zemin); }
.cagri.bilgi svg { color: var(--vurgu); }
.cagri b { font-weight: 650; }

/* ── ana sayfa ── */
.kahraman { padding: 26px 28px; margin-bottom: 20px; display: grid; grid-template-columns: minmax(0,1fr) minmax(0,1.1fr); gap: 26px; align-items: center; }
@media (max-width: 900px) { .kahraman { grid-template-columns: 1fr; } }
.kahraman h1 { font-size: 30px; letter-spacing: -.02em; margin-bottom: 8px; }
.kahraman p { color: var(--murekkep-2); max-width: 52ch; }
.dongu { display: grid; grid-template-columns: repeat(4, 1fr); gap: 0; position: relative; }
.dongu-adim { text-align: center; padding: 0 6px; position: relative; }
.dongu-adim::before { content: ""; position: absolute; top: 22px; left: 50%; width: 100%; height: 2px; background: var(--eksen); }
.dongu-adim:last-child::before { display: none; }
.dongu-simge { position: relative; z-index: 1; width: 46px; height: 46px; margin: 0 auto 8px; border-radius: 50%;
  background: var(--yuzey); border: 2px solid var(--vurgu); color: var(--vurgu); display: grid; place-items: center; }
.dongu-adim b { display: block; font-size: 14px; }
.dongu-adim span { font-size: 12px; color: var(--murekkep-2); display: block; line-height: 1.35; }

.arac-cubugu { display: flex; gap: 12px; flex-wrap: wrap; align-items: center; margin-bottom: 16px; }
.arama { flex: 1 1 260px; position: relative; }
.arama input { width: 100%; padding: 11px 14px 11px 38px; border-radius: 10px; border: 1px solid var(--cizgi);
  background: var(--yuzey); color: var(--murekkep); font: inherit; outline: none; }
.arama input:focus { border-color: var(--vurgu); box-shadow: 0 0 0 3px var(--vurgu-zemin); }
.arama svg { position: absolute; left: 12px; top: 50%; transform: translateY(-50%); color: var(--soluk); }
.cipler { display: flex; gap: 6px; flex-wrap: wrap; }
.cip { padding: 7px 13px; border-radius: 999px; border: 1px solid var(--cizgi); background: var(--yuzey); font-size: 13px; font-weight: 550;
  color: var(--murekkep-2); display: inline-flex; align-items: center; gap: 7px; }
.cip .nokta { width: 9px; height: 9px; border-radius: 50%; background: var(--sinif, var(--soluk)); }
.cip:hover { background: var(--yuzey-2); }
.cip.aktif { background: var(--murekkep); color: var(--yuzey); border-color: var(--murekkep); }

.grup-baslik { display: flex; align-items: center; gap: 10px; margin: 22px 0 10px; font-size: 13px; font-weight: 700;
  text-transform: uppercase; letter-spacing: .06em; color: var(--murekkep-2); }
.grup-baslik .nokta { width: 10px; height: 10px; border-radius: 50%; background: var(--sinif); }
.grup-baslik .sayi { color: var(--soluk); font-weight: 500; }
.ilac-izgara { display: grid; grid-template-columns: repeat(auto-fill, minmax(250px, 1fr)); gap: 12px; }
.ilac-kart { display: flex; flex-direction: column; padding: 14px 16px 13px; color: inherit; border-left: 4px solid var(--sinif); transition: transform .12s, box-shadow .12s; }
.ilac-kart:hover { text-decoration: none; transform: translateY(-2px); box-shadow: 0 2px 4px rgba(11,11,11,.06), 0 12px 28px rgba(11,11,11,.09); }
.ilac-kart h3 { font-size: 16.5px; margin-bottom: 2px; }
.ilac-kart .alt-sinif { font-size: 12.5px; color: var(--murekkep-2); margin-bottom: 10px; }
/* etiket sütunu sığdığı sürece tek satır; değer sütunu en uzun sözcükten dar olamaz (sözcük bölünmez, gerekirse etiket iki satıra iner) */
.ilac-kart .satir { display: grid; grid-template-columns: auto minmax(min-content, 1fr); column-gap: 10px; font-size: 12.5px; padding: 3px 0; border-top: 1px dashed var(--cizgi); }
.ilac-kart .satir span:first-child { color: var(--soluk); flex: none; }
.ilac-kart .satir span:last-child { text-align: right; font-weight: 550; }
/* kartın alt etiketleri: tek kapsayıcıda, her tasarımda aynı sol hizada; kart yüksekliği satırda eşitlendiğinde en altta toplanır */
.ilac-kart .kart-etiketler { display: flex; flex-wrap: wrap; align-items: flex-start; gap: 6px; margin-top: auto; padding-top: 9px; }
.ilac-kart .kart-etiketler .etiket { margin: 0; max-width: 100%; }
.bos { padding: 40px; text-align: center; color: var(--murekkep-2); }

/* ── ilaç ayrıntı ── */
.geri { display: inline-flex; align-items: center; gap: 6px; font-size: 13.5px; margin-bottom: 12px; color: var(--murekkep-2); }
.ilac-bas { padding: 24px 26px; margin-bottom: 14px; border-top: 5px solid var(--sinif); }
.ilac-bas h1 { font-size: 30px; letter-spacing: -.02em; }
.ilac-bas .ust-satir { display: flex; align-items: center; gap: 12px; flex-wrap: wrap; margin-bottom: 6px; }
.ilac-bas .mek { color: var(--murekkep-2); max-width: 80ch; margin-bottom: 14px; }
.onaylar { display: flex; gap: 6px; flex-wrap: wrap; margin-bottom: 16px; }
.kutular { display: grid; grid-template-columns: repeat(auto-fit, minmax(170px, 1fr)); gap: 10px; }
.kutu { background: var(--yuzey-2); border-radius: 10px; padding: 11px 13px; }
.kutu .ad { font-size: 11.5px; text-transform: uppercase; letter-spacing: .05em; color: var(--soluk); font-weight: 650; }
.kutu .deger { font-size: 15px; font-weight: 650; margin-top: 2px; line-height: 1.3; }
.kutu .not { font-size: 12px; color: var(--murekkep-2); margin-top: 2px; }
.kutu.vurgulu { background: color-mix(in srgb, var(--sinif) 12%, var(--yuzey)); }

.yol { position: sticky; top: calc(var(--ust-h, 56px) - 1px); z-index: 10; display: grid; grid-template-columns: repeat(7, 1fr); gap: 0; padding: 8px 10px;
  margin-bottom: 18px; background: color-mix(in srgb, var(--yuzey) 94%, transparent); backdrop-filter: blur(10px); }
.yol a { display: flex; align-items: center; justify-content: center; gap: 8px; padding: 7px 4px; border-radius: 8px; font-size: 13px;
  font-weight: 600; color: var(--murekkep-2); position: relative; }
.yol a:hover { background: var(--yuzey-2); text-decoration: none; color: var(--murekkep); }
.yol a .no { width: 22px; height: 22px; font-size: 12px; }
@media (max-width: 760px) { .yol { grid-template-columns: repeat(3, 1fr); position: static; } }

.sekmeler { display: inline-flex; padding: 3px; background: var(--yuzey-2); border-radius: 10px; margin-bottom: 14px; }
.sekmeler button { border: 0; background: transparent; padding: 7px 14px; border-radius: 8px; font-size: 13.5px; font-weight: 600; color: var(--murekkep-2); }
.sekmeler button.aktif { background: var(--yuzey); color: var(--murekkep); box-shadow: 0 1px 3px rgba(0,0,0,.12); }

.doz-kutular { display: grid; grid-template-columns: 1fr 1fr; gap: 10px; }
.grafik-kutu { border: 1px solid var(--cizgi); border-radius: 12px; padding: 12px 12px 8px; background: var(--yuzey); }
.grafik-baslik { font-size: 13px; font-weight: 650; margin-bottom: 2px; }
.grafik-alt { font-size: 12px; color: var(--murekkep-2); margin-bottom: 6px; }
.grafik-kutu svg { display: block; width: 100%; height: auto; overflow: visible; }
.lejant { display: flex; gap: 14px; flex-wrap: wrap; font-size: 12px; color: var(--murekkep-2); margin-top: 6px; }
.lejant i { display: inline-block; width: 14px; height: 3px; border-radius: 2px; vertical-align: middle; margin-right: 5px; background: var(--renk); }
.lejant i.bant { height: 10px; opacity: .28; }
.lejant i.kesik { background: repeating-linear-gradient(90deg, var(--renk) 0 4px, transparent 4px 7px); }
.notlar { margin-top: 12px; }
.notlar li { font-size: 14px; }

/* SVG metin */
svg text { font-family: system-ui, -apple-system, "Segoe UI", sans-serif; }
.g-eksen { fill: var(--soluk); font-size: 11px; font-variant-numeric: tabular-nums; }
.g-etiket { fill: var(--murekkep); font-size: 12px; font-weight: 650; }
.g-ikincil { fill: var(--murekkep-2); font-size: 11px; }
.g-cizgi { stroke: var(--cizgi); stroke-width: 1; }
.g-taban { stroke: var(--eksen); stroke-width: 1; }
.g-nokta { cursor: default; }

/* risk ölçer */
.olcer { display: flex; gap: 3px; margin: 6px 0 4px; }
.olcer i { flex: 1; height: 8px; border-radius: 4px; background: var(--yuzey-2); border: 1px solid var(--cizgi); }
.olcer i.dolu { background: var(--renk); border-color: transparent; }

/* yarı ömür cetveli */
.cetvel { position: relative; height: 40px; margin: 8px 4px 0; }
.cetvel .ray { position: absolute; left: 0; right: 0; top: 8px; height: 6px; border-radius: 3px;
  background: linear-gradient(90deg, var(--ton-1), var(--ton-3)); }
.cetvel .im { position: absolute; top: 1px; width: 20px; height: 20px; margin-left: -10px; border-radius: 50%;
  background: var(--yuzey); border: 4px solid var(--ton-4); }
.cetvel .cent { position: absolute; top: 24px; transform: translateX(-50%); font-size: 10.5px; color: var(--soluk); white-space: nowrap; }
.cetvel .cent::before { content: ""; position: absolute; left: 50%; top: -12px; width: 1px; height: 8px; background: var(--eksen); }

/* izlem matrisi */
.matris-sar { overflow-x: auto; }
table.matris { width: 100%; border-collapse: collapse; font-size: 13.5px; min-width: 640px; }
table.matris th { font-size: 12px; font-weight: 650; color: var(--murekkep-2); text-align: center; padding: 8px 6px; border-bottom: 2px solid var(--cizgi); }
table.matris th:first-child, table.matris td:first-child { text-align: left; padding-left: 0; }
table.matris td { padding: 8px 6px; border-bottom: 1px solid var(--cizgi); text-align: center; vertical-align: middle; }
table.matris td:first-child { font-weight: 600; width: 30%; }
table.matris td.aciklama { text-align: left; font-size: 12.5px; color: var(--murekkep-2); width: 28%; }
table.matris tr:hover td { background: var(--yuzey-2); }
.isaret { display: inline-block; width: 15px; height: 15px; border-radius: 50%; vertical-align: middle; }
.isaret.dolu { background: var(--sinif, var(--vurgu)); }
.isaret.halka { border: 2.5px solid var(--sinif, var(--vurgu)); }
.isaret.yok { width: 8px; height: 2px; border-radius: 1px; background: var(--eksen); }
.hucre-yazi { font-size: 11.5px; font-weight: 650; background: color-mix(in srgb, var(--sinif, var(--vurgu)) 14%, var(--yuzey)); padding: 3px 7px; border-radius: 6px; display: inline-block; line-height: 1.3; }
.matris-lejant { display: flex; gap: 18px; flex-wrap: wrap; font-size: 12.5px; color: var(--murekkep-2); margin-top: 12px; align-items: center; }
.matris-lejant span { display: inline-flex; align-items: center; gap: 6px; }

/* yan etki profili */
.profil { display: grid; grid-template-columns: repeat(auto-fill, minmax(190px, 1fr)); gap: 8px 22px; }
.profil-satir { display: grid; grid-template-columns: 1fr auto; align-items: center; gap: 10px; padding: 5px 0; border-bottom: 1px solid var(--cizgi); font-size: 13.5px; }
.pipler { display: flex; gap: 3px; }
.pipler i { width: 18px; height: 10px; border-radius: 3px; background: var(--yuzey-2); border: 1px solid var(--cizgi); }
.pipler i.d1 { background: var(--ton-2); border-color: transparent; }
.pipler i.d2 { background: var(--ton-3); border-color: transparent; }
.pipler i.d3 { background: var(--ton-4); border-color: transparent; }
.iki-sutun { display: grid; grid-template-columns: 1fr 1fr; gap: 22px; }
@media (max-width: 760px) { .iki-sutun { grid-template-columns: 1fr; } .doz-kutular { grid-template-columns: 1fr; } }
.iki-sutun h3, .alt-b { font-size: 13px; text-transform: uppercase; letter-spacing: .05em; color: var(--soluk); margin: 14px 0 6px; font-weight: 700; }

/* ── değişim aracı ── */
.secici { display: grid; grid-template-columns: 1fr auto 1fr; gap: 14px; align-items: end; margin-bottom: 6px; }
@media (max-width: 700px) { .secici { grid-template-columns: 1fr; } .secici .ok { transform: rotate(90deg); justify-self: center; } }
.secici label { display: block; font-size: 12px; font-weight: 700; text-transform: uppercase; letter-spacing: .05em; color: var(--soluk); margin-bottom: 5px; }
.secici select { width: 100%; padding: 11px 12px; border-radius: 10px; border: 1px solid var(--cizgi); background: var(--yuzey); color: var(--murekkep); font: inherit; font-weight: 600; }
.secici .ok { color: var(--soluk); padding-bottom: 9px; }
.strateji-bas { display: flex; align-items: center; gap: 12px; flex-wrap: wrap; margin-bottom: 4px; }
.strateji-bas h2 { font-size: 22px; }
.adimlar { counter-reset: adim; list-style: none; padding: 0; margin: 0; }
.adimlar li { counter-increment: adim; position: relative; padding: 0 0 14px 40px; margin: 0; }
.adimlar li::before { content: counter(adim); position: absolute; left: 0; top: 0; width: 26px; height: 26px; border-radius: 50%;
  background: var(--vurgu); color: #fff; font-size: 13px; font-weight: 700; display: grid; place-items: center; }
.adimlar li::after { content: ""; position: absolute; left: 12.5px; top: 30px; bottom: 2px; width: 1.5px; background: var(--cizgi); }
.adimlar li:last-child::after { display: none; }
.strateji-izgara { display: grid; grid-template-columns: repeat(4, 1fr); gap: 10px; }
@media (max-width: 820px) { .strateji-izgara { grid-template-columns: repeat(2, 1fr); } }
.strateji-mini { padding: 12px; border: 1px solid var(--cizgi); border-radius: 12px; background: var(--yuzey); }
.strateji-mini.secili { border-color: var(--vurgu); box-shadow: 0 0 0 3px var(--vurgu-zemin); }
.strateji-mini b { font-size: 13.5px; display: block; }
.strateji-mini span { font-size: 12px; color: var(--murekkep-2); display: block; line-height: 1.35; margin-top: 2px; }

/* ── akış şeması ── */
.akis { display: flex; flex-direction: column; align-items: center; gap: 0; }
.akis-dugum { border: 1.5px solid var(--eksen); background: var(--yuzey); border-radius: 12px; padding: 10px 16px; text-align: center;
  max-width: 520px; width: 100%; font-size: 14px; }
.akis-dugum b { display: block; font-size: 14.5px; }
.akis-dugum span { color: var(--murekkep-2); font-size: 12.5px; }
.akis-dugum.karar { border-color: var(--vurgu); background: var(--vurgu-zemin); border-radius: 999px; max-width: 380px; }
.akis-dugum.son { border-color: var(--iyi); background: var(--iyi-zemin); }
.akis-dugum.dikkat { border-color: var(--uyari); background: var(--uyari-zemin); }
.akis-ok { width: 2px; height: 22px; background: var(--eksen); position: relative; }
.akis-ok::after { content: ""; position: absolute; left: -4px; bottom: -1px; border: 5px solid transparent; border-top: 7px solid var(--eksen); border-bottom: 0; }
.akis-dal { display: grid; grid-template-columns: 1fr 1fr; gap: 18px; width: 100%; max-width: 760px; position: relative; padding-top: 22px; }
.akis-dal::before { content: ""; position: absolute; top: 0; left: 25%; right: 25%; height: 22px; border: 2px solid var(--eksen); border-bottom: 0; border-radius: 10px 10px 0 0; }
.akis-kol { display: flex; flex-direction: column; align-items: center; }
.akis-kol .dal-etiket { font-size: 11.5px; font-weight: 700; text-transform: uppercase; letter-spacing: .05em; color: var(--murekkep-2);
  background: var(--yuzey); padding: 1px 8px; border-radius: 999px; border: 1px solid var(--cizgi); margin: -10px 0 6px; position: relative; z-index: 1; }

.zaman-seridi { display: grid; grid-template-columns: 1.2fr 2.4fr 1fr; gap: 3px; margin: 12px 0 6px; }
.zaman-seridi div { padding: 10px 12px; color: #fff; font-size: 13px; line-height: 1.3; }
.zaman-seridi div:first-child { border-radius: 10px 4px 4px 10px; background: var(--ton-2); color: #0b0b0b; }
.zaman-seridi div:nth-child(2) { background: var(--ton-3); border-radius: 4px; }
.zaman-seridi div:last-child { border-radius: 4px 10px 10px 4px; background: var(--ton-4); }
:root[data-theme="dark"] .zaman-seridi div:last-child { color: #0b0b0b; }
.zaman-seridi b { display: block; font-size: 14px; }

.ilke-izgara { display: grid; grid-template-columns: repeat(auto-fill, minmax(250px, 1fr)); gap: 12px; }
.ilke { padding: 14px 16px; border: 1px solid var(--cizgi); border-radius: 12px; background: var(--yuzey); }
.ilke .simge { width: 34px; height: 34px; border-radius: 9px; background: var(--vurgu-zemin); color: var(--vurgu); display: grid; place-items: center; margin-bottom: 8px; }
.ilke b { display: block; margin-bottom: 3px; }
.ilke p, .ilke li { font-size: 13.5px; color: var(--murekkep-2); margin: 0; }
.ilke.acil { border-left: 4px solid var(--kritik); }
.ilke.acil .ilk-adim { margin-top: 8px; padding-top: 8px; border-top: 1px dashed var(--cizgi); font-size: 13px; color: var(--murekkep); }
.harf-izgara { display: grid; grid-template-columns: repeat(6, 1fr); gap: 8px; }
@media (max-width: 760px) { .harf-izgara { grid-template-columns: repeat(2, 1fr); } }
.harf { text-align: center; padding: 12px 8px; background: var(--yuzey-2); border-radius: 12px; }
.harf .h { font-size: 28px; font-weight: 800; color: var(--vurgu); line-height: 1; }
.harf b { display: block; font-size: 13px; margin-top: 4px; }
.harf span { font-size: 12px; color: var(--murekkep-2); display: block; line-height: 1.3; }

.esikler { display: grid; grid-template-columns: repeat(auto-fill, minmax(230px, 1fr)); gap: 10px; }
.esik { background: var(--yuzey-2); border-radius: 10px; padding: 11px 13px; }
.esik .ad { font-size: 12px; font-weight: 700; color: var(--murekkep-2); }
.esik .deger { font-size: 17px; font-weight: 700; margin: 2px 0; }
.esik .not { font-size: 12.5px; color: var(--murekkep-2); }

/* yarı ömür sıralama grafiği */
.yo-liste { display: grid; grid-template-columns: 150px 1fr 90px; gap: 5px 10px; align-items: center; font-size: 13px; }
.yo-liste .cubuk-ray { height: 12px; position: relative; }
.yo-liste .cubuk { position: absolute; left: 0; top: 0; bottom: 0; background: var(--sinif); border-radius: 0 4px 4px 0; min-width: 3px; }
.yo-liste .deger { font-variant-numeric: tabular-nums; color: var(--murekkep-2); font-size: 12.5px; }
.yo-liste a { color: var(--murekkep); }
.yo-liste .cubuk-ray { background: var(--yuzey-2); border-radius: 0 4px 4px 0; }
.yo-liste.depo-ozet { grid-template-columns: 250px 1fr 220px; }
a.etiket:hover { text-decoration: none; background: var(--vurgu-zemin); color: var(--vurgu); }
.yo-ray { position: relative; height: 16px; }
.yo-ray::before { content: ""; position: absolute; left: 0; right: 0; top: 7.5px; height: 1px; background: var(--cizgi); }
.yo-nokta { position: absolute; top: 2px; width: 12px; height: 12px; margin-left: -6px; border-radius: 50%; background: var(--sinif);
  box-shadow: 0 0 0 2px var(--yuzey); }
.yo-eksen { position: relative; height: 18px; }
.yo-eksen span { position: absolute; transform: translateX(-50%); font-size: 11px; color: var(--soluk); white-space: nowrap; }
@media (max-width: 700px) { .yo-liste { grid-template-columns: 110px 1fr 70px !important; font-size: 12px; } }

/* ── metabolizma / CYP ── */
:root { --rol-sub: var(--s-ad); --rol-inh: var(--s-dehb); --rol-ind: var(--s-dd); }
.rz { display: inline-flex; align-items: center; padding: 2px 7px; margin: 1px; border-radius: 6px; font-size: 11.5px; font-weight: 650; line-height: 1.35;
  color: var(--murekkep); border: 1.5px solid transparent; white-space: nowrap; }
.rz.g3 { background: color-mix(in srgb, var(--rol) 30%, var(--yuzey)); border-color: var(--rol); }
.rz.g2 { background: color-mix(in srgb, var(--rol) 13%, var(--yuzey)); border-color: color-mix(in srgb, var(--rol) 55%, var(--yuzey)); }
.rz.g1 { background: transparent; border: 1.5px dashed color-mix(in srgb, var(--rol) 65%, var(--yuzey)); color: var(--murekkep-2); font-weight: 550; }
a.rz:hover { text-decoration: none; box-shadow: 0 0 0 2px var(--vurgu-zemin); }
.metab-ozet { max-width: 90ch; font-size: 14.5px; }
.metab-akis { display: grid; grid-template-columns: minmax(0, 1fr) 30px minmax(0, 1fr) 30px minmax(0, 1fr); margin: 14px 0 6px; }
.metab-kutu { border: 1.5px solid var(--eksen); border-radius: 12px; padding: 12px 14px; background: var(--yuzey); }
.metab-kutu .ad { font-size: 11.5px; text-transform: uppercase; letter-spacing: .05em; color: var(--soluk); font-weight: 650; }
.metab-kutu .metin, p.metin { font-size: 13.5px; margin: 8px 0 0; }
.metab-ok { align-self: center; height: 2px; background: var(--eksen); position: relative; margin: 0 3px 0 0; }
.metab-ok::after { content: ""; position: absolute; right: -3px; top: -4px; border: 5px solid transparent; border-left: 7px solid var(--eksen); border-right: 0; }
@media (max-width: 860px) {
  .metab-akis { grid-template-columns: 1fr; }
  .metab-ok { width: 2px; height: 20px; justify-self: center; margin: 0; }
  .metab-ok::after { right: auto; left: -4px; top: auto; bottom: -3px; border: 5px solid transparent; border-top: 7px solid var(--eksen); border-bottom: 0; }
}
.enzler { display: flex; flex-wrap: wrap; gap: 6px; margin-top: 8px; }
.enz { display: inline-flex; flex-direction: column; padding: 5px 10px; border-radius: 9px; border: 1.5px solid var(--eksen); color: var(--murekkep); line-height: 1.25; max-width: 100%; }
.enz b { font-size: 14px; font-weight: 700; }
.enz span { font-size: 11px; color: var(--murekkep-2); }
.enz.ana { background: color-mix(in srgb, var(--rol-sub) 22%, var(--yuzey)); border-color: var(--rol-sub); }
.enz.kucuk { border-style: dashed; border-color: color-mix(in srgb, var(--rol-sub) 60%, var(--yuzey)); }
.enz.kucuk b { font-weight: 600; }
.enz.diger { background: var(--yuzey-2); border-color: var(--cizgi); }
.enz.diger b { font-size: 13px; font-weight: 600; }
a.enz:hover { text-decoration: none; box-shadow: 0 0 0 3px var(--vurgu-zemin); }
.atilim-cubuk { display: flex; gap: 2px; height: 14px; margin: 10px 0 7px; }
.atilim-cubuk i { display: block; height: 100%; border-radius: 3px; min-width: 3px; padding: 0; }
.atilim-cubuk .idrar, .atilim-lejant .idrar { background: var(--s-ad); }
.atilim-cubuk .diski, .atilim-lejant .diski { background: var(--soluk); }
.atilim-cubuk .bos { background: var(--yuzey-2); }
.atilim-lejant { display: flex; gap: 14px; flex-wrap: wrap; font-size: 12.5px; color: var(--murekkep-2); }
.atilim-lejant i { display: inline-block; width: 10px; height: 10px; border-radius: 3px; margin-right: 5px; vertical-align: -1px; }
.fe { margin-top: 10px; padding-top: 9px; border-top: 1px dashed var(--cizgi); font-size: 13px; }
.fe-ray { height: 6px; border-radius: 3px; background: var(--yuzey-2); margin-top: 6px; position: relative; overflow: hidden; }
.fe-ray i { position: absolute; left: 0; top: 0; bottom: 0; background: var(--ton-4); border-radius: 3px; min-width: 3px; }
table.matris.cyp-tablo { min-width: 620px; }
table.matris.cyp-tablo td:first-child { width: 20%; }
table.matris th a { color: inherit; }
.rol-alt { display: block; font-size: 11.5px; font-weight: 450; color: var(--soluk); }
.metin-kutular { margin-top: 14px; grid-template-columns: repeat(auto-fit, minmax(230px, 1fr)); }
.metin-kutular .kutu .deger { font-size: 13.5px; font-weight: 450; line-height: 1.45; margin-top: 4px; }
.komsu { display: grid; grid-template-columns: 230px 1fr; gap: 6px 14px; padding: 8px 0; border-top: 1px solid var(--cizgi); align-items: start; }
.komsu-ad { font-size: 13px; font-weight: 600; padding-top: 3px; }
.komsu-liste { display: flex; flex-wrap: wrap; gap: 5px; }
@media (max-width: 700px) { .komsu { grid-template-columns: 1fr; } }
.formul { display: flex; align-items: center; gap: 4px; flex-wrap: wrap; margin-bottom: 8px; }
.formul .rz { font-size: 12.5px; padding: 3px 9px; }
.formul .arti { color: var(--soluk); font-weight: 700; }
.ilke-izgara + .cagri { margin-top: 14px; }
a.cip:hover { text-decoration: none; }
.enzim-kart { border: 1.5px solid var(--vurgu); border-radius: 12px; padding: 14px 16px; margin-bottom: 16px; background: var(--yuzey); }
.enzim-bas { display: grid; grid-template-columns: auto 1fr; gap: 14px; align-items: baseline; margin-bottom: 4px; }
.enzim-bas b { font-size: 22px; letter-spacing: -.01em; }
.enzim-bas span { font-size: 13.5px; color: var(--murekkep-2); }
.enzim-izgara { display: grid; grid-template-columns: repeat(3, minmax(0, 1fr)); gap: 18px; }
@media (max-width: 820px) { .enzim-izgara { grid-template-columns: 1fr; gap: 4px; } .enzim-bas { grid-template-columns: 1fr; gap: 2px; } }
.enzim-kol h3 { font-size: 13px; text-transform: uppercase; letter-spacing: .05em; color: var(--soluk); margin: 12px 0 7px; font-weight: 700; }
.enzim-kol .dis { font-size: 12.5px; color: var(--murekkep-2); margin-top: 9px; padding-top: 8px; border-top: 1px dashed var(--cizgi); }
.enzim-kol .dis b { color: var(--murekkep); font-weight: 600; }
table.matris.cyp-harita { min-width: 760px; }
table.matris.cyp-harita td:first-child { width: 19%; }
table.matris.cyp-harita td { padding: 6px 4px; }
table.matris.cyp-harita td.aciklama { width: 21%; }
table.matris .secili { background: var(--vurgu-zemin); }
table.matris tr.grup-satir td { font-size: 11.5px; font-weight: 700; text-transform: uppercase; letter-spacing: .06em; color: var(--murekkep-2);
  text-align: left; padding: 14px 0 5px; border-bottom: 2px solid var(--cizgi); width: auto; }
table.matris tr.grup-satir:hover td { background: transparent; }
table.matris tr.grup-satir .nokta { display: inline-block; width: 9px; height: 9px; border-radius: 50%; background: var(--sinif); margin-right: 8px; }
table.matris tr.grup-satir .sayi { color: var(--soluk); font-weight: 500; letter-spacing: 0; text-transform: none; margin-left: 6px; }
table.matris tr.iliskisiz td { text-align: left; font-size: 12.5px; font-weight: 450; color: var(--murekkep-2); padding: 7px 0; width: auto; line-height: 1.7; }
table.matris tr.iliskisiz td b { font-weight: 600; }
table.matris tr.iliskisiz .yapisik { position: sticky; left: 0; width: min(100%, calc(100vw - 108px)); }
table.matris tr.iliskisiz:hover td { background: transparent; }
table.matris.metin-tablo td { text-align: left; font-size: 13px; vertical-align: top; }
table.matris.metin-tablo th { text-align: left; }
table.matris.metin-tablo td:first-child { width: 18%; }

.ipucu { position: fixed; z-index: 50; pointer-events: none; background: var(--murekkep); color: var(--yuzey); font-size: 12.5px;
  padding: 6px 10px; border-radius: 8px; max-width: 260px; line-height: 1.35; box-shadow: 0 4px 14px rgba(0,0,0,.25); }
.ipucu b { display: block; }

@media print {
  .ust, .yol, .tema-dugme, .geri { display: none !important; }
  .kart { box-shadow: none; break-inside: avoid; }
}

/* Özel kullanım paneli (ör. alkol yoksunluğunda benzodiazepin) */
.ozel-kullanim { margin-top: 22px; padding-top: 4px; border-top: 1px dashed var(--cizgi); }
.ozel-kullanim .alt-b { display: flex; align-items: center; gap: 8px; flex-wrap: wrap; }
.ozel-kullanim .alt-b .etiket { text-transform: none; letter-spacing: 0; }
.ozel-kullanim table.matris th, .ozel-kullanim table.matris td { text-align: left; }
.ozel-kullanim table.matris td:first-child { width: 20%; }
.ozel-kullanim .kucuk a { font-weight: 600; }